Why the study?
What is the immunological mechanism of profound thrombocytopenia following a second exposure to abciximab?
Population
9 patients who developed profound thrombocytopenia within a few hours of a second exposure to abciximab, and…
Comparison
Second exposure to abciximab vs Healthy subjects (for antibody comparison)
Design
Case-control
Authors
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Murine-specific antibodies may mediate abciximab thrombocytopenia on re-exposure; hypothesis-generating for screening validation.
What is the immunological mechanism of profound thrombocytopenia following a second exposure to abciximab?
Severe thrombocytopenia after a second abciximab exposure is caused by patient-specific antibodies targeting the murine sequences of the drug, suggesting a potential screening strategy using 7E3-coated platelets.
Curtis et al. (2002) studied this question.
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