The therapeutic activity of the formulations is obtained by disintegration followed by dissolution. The inclusion of right disintegrant is a prerequisite to get optimal bioavailability in tablets and capsules. Disintegrants are the substances that causes rapid disintegration of the capsules or tablets into smaller particles that dissolves more rapidly than in the absence of the disintegrants. On the other hand, superdisintegrants, as it name suggests superior to disintegrants are the substances which facilitates or increases the disintegration time even at low level, typically 1-10% by weight relative to the total weight of the dosage unit. These are used to increase the effectiveness of solid dosage form. This review article focus on the classification, ideal characteristics, advantages, disadvantages, selection and mechanism of action of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance.
No takes yet. Share an insight, caveat, or question.
Shobana et al. (2020) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: