Deactivation and structural deformation of enzymes immobilized on magnetic nanoparticles (MNPs) are observed after exposure to magnetic fields. These changes are due to realignment of MNPs in response to the AC magnetic field, which leads to stresses in MNP-linked polymer chains. Such stresses translated to an enzyme molecule immobilized on a MNP aggregate induce deformations and irreversible (or long lasting) conformational changes.
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Klyachko et al. (2012) studied this question.
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