Why the study?
Does hypoxia alter the electrophysiological properties of the SA node, atrium, and AV node in isolated rabbit hearts?
Population
Isolated, superfused sinoatrial (SA) node, atrium, and atrioventricular (AV) node of the rabbit heart
Comparison
Hypoxia (gradually decreasing Po2) vs Baseline/normoxic conditions
Design
Preclinical
Authors
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Hypoxia selectively impairs nodal electrophysiology in isolated hearts; leaves open translation to in vivo or human arrhythmias.
Does hypoxia alter the electrophysiological properties of the SA node, atrium, and AV node in isolated rabbit hearts?
Acute hypoxia predominantly inhibits slow response activity in the SA and AV nodes but has little effect on the fast inward sodium current in the atrium.
Senges et al. (1979) studied this question.
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