Do Glucocorticoids Play a Role in Patients with Temporal Lobe Epilepsy and, Depression and Anxiety? A Systematic Review

Temporal Lobe Epilepsy (TLE) is one of the most frequent epilepsy syndromes associated with a high prevalence of psychiatric disorders (PD), particularly depression and anxiety.Stress levels associated with depression and anxiety can be related to alterations in glucocorticoid receptors, which play a role in hippocampal formation.In this study, we systematically reviewed the role of glucocorticoids acting by binding to their receptors in the temporal lobe of patients with TLE associated with depressive and anxiety disorders.The PubMed, PsycINFO, and Scielo databases were searched for relevant articles published in the last ten years.There have been relatively few published studies with different methodologies and contradicting conclusions regarding the association between TLE, depression, anxiety, and glucocorticoid receptors.Four articles were selected for this review after applying the inclusion and exclusion criteria.This indicates the necessity for more investigations into this topic.