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March 15, 2004Biochemical JournalOpen Access

Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone

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Population

dexamethasone-injected mouse and primary hepatocyte models

Comparison

dexamethasone vs control mice

Design

Preclinical

Authors

VDVernon W. DolinskyChildren's Hospital Research Institute of ManitobaDDDonna N. DouglasUniversity of AlbertaRLRichard LehnerUniversity of Alberta

Discussion

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Implication

Dexamethasone effects on hepatic TAG in animals should not yet change practice; extends mechanistic insight into glucocorticoid lipid handling.

Structured PICO

P
Population
dexamethasone-injected mouse and primary hepatocyte models
I
Intervention
dexamethasone
C
Comparator
control mice
O
Outcome
alteration of hepatic lipolysis and re-esterification and the provision of stored TAG for lipoprotein secretionsurrogate

Dexamethasone alters hepatic lipid metabolism by diverting de novo synthesized TAG directly for VLDL assembly while reducing the utilization of stored TAG.

Cite This Study

Dolinsky et al. (2004) studied this question.

synapsesocial.com/papers/6a6fabd226a7f98052dc4a02https://doi.org/10.1042/bj20031320
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation1997 · 105 citations
  2. 2Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue1996 · 40 citations
  3. 3Depressed Plasma FFA Turnover Rate in Cushing’s Syndrome1976 · 14 citations
  4. 4Dexamethasone Destabilizes Cyclooxygenase 2 mRNA by Inhibiting Mitogen-Activated Protein Kinase p382001 · 260 citations
  5. 5Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification1998 · 120 citations