A systematic study of fatty acylated polyarginines as drug-delivery modules is described. A remarkable uptake was observed when a myristate moiety was incorporated with a 7-mer polyarginine (see scheme). Microscopic studies suggest that the fatty acylated peptide is internalized into the cytoplasm, not the nucleus, thus providing an alternative method for drug delivery.
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Pham et al. (2004) studied this question.
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