Relationship between LINC00341 expression and cancer prognosis

// Meijian Liao 1, 2, * , Bing Li 1, 2, * , Shikuan Zhang 2 , Qing Liu 1, 2 , Weijie Liao 1, 2 , Weidong Xie 2, 3 , Yaou Zhang 2, 3 1 School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China 2 Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P.R. China 3 Open FIESTA Center, Tsinghua University, Shenzhen 518055, P.R. China * These authors contributed equally to this work Correspondence to: Weidong Xie, email: xiewd@sz.tsinghua.edu.cn Yaou Zhang, email: zhangyo@sz.tsinghua.edu.cn Keywords: LncRNA, LINC00341, metastasis, meta-analysis, prognostication Received: November 15, 2016      Accepted: January 17, 2017      Published: January 27, 2017 ABSTRACT LINC00341 is a novel long intergenic non-protein coding RNA with unknown functions. In our report, we investigated LINC00341 expression and its prognostic value in cancer patients. DNA over-methylation triggered low expression of LINC00341 and that was associated with poor prognosis in cancers. A meta-analysis further confirmed that high expression of LINC00341 was associated with a better prognosis in cancer patients. Both gene set enrichment analysis and meta-analysis showed that LINC00341 inhibited cancer metastasis. Finally, a large-scale multicentre analysis supported a prognostic value of LINC00341 in cancers.