The purified porin of Shigella dysenteriae type 1 showed strong mitogenic activity for murine splenocytes. Preincubation of S. dysenteriae type 1 with anti-porin antibody reduced the bacterial plaque formation in HeLa cell monolayers by 45%. The two immunobiological activities indicate that porin might be important in the induction of protective immunity against shigellosis.
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Roy et al. (1996) studied this question.
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