What question did this study set out to answer?

To determine whether AT1 receptor blockade using losartan reduces fatty-streak formation, alters plasma lipid profiles, or suppresses surrogate markers of vascular injury in a nonhuman primate model of diet-induced atherosclerosis.

April 4, 2000CirculationOpen Access

Inhibition of Early Atherogenesis by Losartan in Monkeys With Diet-Induced Hypercholesterolemia

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Why the study?

Does losartan reduce fatty-streak formation in male cynomolgus monkeys with diet-induced hypercholesterolemia?

Key Points

To determine whether AT1 receptor blockade using losartan reduces fatty-streak formation, alters plasma lipid profiles, or suppresses surrogate markers of vascular injury in a nonhuman primate model of diet-induced atherosclerosis.
Male cynomolgus monkeys were fed a high-cholesterol diet (0.067 mg cholesterol/kJ) for 20 weeks.
At week 12 of the dietary regimen, monkeys were administered either losartan (180 mg/d, n=6) or vehicle (n=8) for 6 weeks.
Losartan reduced the extent of fatty-streak lesions in the aorta, coronary arteries, and carotid arteries by approximately 50% compared with vehicle controls (P < 0.05).
Treatment produced a significant reduction in the susceptibility of LDL to in vitro oxidation, circulating monocyte CD11b expression, and serum monocyte chemoattractant protein-1 levels (P < 0.05), without altering arterial blood pressure, heart rate, or plasma cholesterol profiles.

Structured PICO

Does losartan reduce fatty-streak formation in male cynomolgus monkeys with diet-induced hypercholesterolemia?

Population

14 male cynomolgus monkeys fed a diet containing 0.067 mg cholesterol/kJ for 20 weeks

Intervention

Losartan 180 mg/d for 6 weeks starting at week 12 of the dietary regimen

Comparator

Vehicle for 6 weeks starting at week 12 of the dietary regimen

Outcome

Extent of fatty streak in the aorta, the coronary arteries, and the carotid arteriessurrogate

AT1 receptor blockade with losartan inhibits early atherogenesis in a nonhuman primate model of diet-induced hypercholesterolemia.

Discussion

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Implication

AT1 blockade may inhibit early atherogenesis in primates; leaves open translation to human atherosclerosis prevention.

Cite This Study

Strawn et al. (2000) studied this question.

synapsesocial.com/papers/6a6fb19e78a11c550e096fa6 https://doi.org/10.1161/01.cir.101.13.1586

View Full Paper

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Inhibition of Early Atherogenesis by Losartan in Monkeys With Diet-Induced Hypercholesterolemia

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Inhibition of Early Atherogenesis by Losartan in Monkeys With Diet-Induced Hypercholesterolemia

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider