Japanese G8 bovine rotavirus strains share similar genetic and serologic characteristics in their VP7 genes, with neutralization differences likely depending on P serotypes/genotypes.
Supports VP7 similarity among Japanese G8 bovine strains; leaves open whether P genotypes explain neutralization variation.
G8 bovine group A rotaviruses isolated in Japan were genetically and serologically characterized. The VP7 gene nucleotide and amino acid sequences revealed high identity with each other. All Japanese G8 strains were classified into the same lineage in the phylogenetic analysis based on VP7 gene sequences. Antisera to four Japanese G8 strains neutralized other G8 strains, but their neutralizing titers were between 8-fold lower and 2-fold higher than homologous strains. These results suggest that the VP7s of Japanese G8 strains have similar genetic and serologic characteristics. Observed differences in the neutralizing abilities of antisera for each strain appear to depend on differences in the P serotypes/genotypes.
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Fukai et al. (2004) studied this question.
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