RVLM presympathetic neurons have intrinsic pacemaking properties, but sympathetic overactivity in neurogenic hypertension is driven by altered synaptic inputs from the respiratory network rather than changes in these intrinsic properties.
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Methodological differences leave RVLM presympathetic pacemaking unresolved; standardized in vivo studies needed before translational relevance.
Accorsi‐Mendonça et al. (2016) studied this question.
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