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April 2, 2021Science ImmunologyOpen Access

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

Jia Jia Lim Claerwen M. Jones Tiing Jen Loh Yi Tian Ting Pirooz Zareie Khai Lee Loh Nathan Felix Anish Suri Murray McKinnon Frederik Stevenaert Ravi Sharma Lars Klareskog Vivianne Malmström Daniel G. Baker Anthony W. Purcell Hugh H. Reid Nicole L. La Gruta Jamie Rossjohn

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Abstract

Citrullination of a fibrinogen peptide influences HLA-DR4 binding and TCR usage by neoepitope-reactive T cells in rheumatoid arthritis.

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Lim et al. (2021) studied this question.

synapsesocial.com/papers/6a6fbe932163a0a01bc4037d https://doi.org/10.1126/sciimmunol.abe0896

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Adaptable Major Histocompatibility Complex (MHC) Fold: Structure and Function of Nonclassical and MHC Class I–Like MoleculesReview · 2013 · 203 citations
2Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.Diagnostic Study · 1995 · 310 citations
3Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusionOriginal Research · 2016 · 504 citations
4A molecular basis for the association of the <i>HLA-DRB1</i> locus, citrullination, and rheumatoid arthritisGenetic Association Study · 2013 · 428 citations
5Immunity to Citrullinated Proteins in Rheumatoid ArthritisReview · 2008 · 463 citations

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The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis2000

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