Key result
Anti-Ro-positive lupus with Sjögren's syndrome carries worse prognosis and more multiorgan disease than SCLE.
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Unlike anti-Ro(SS-A) antibody positive subacute cutaneous lupus erythematosus (SCLE) patients, anti-Ro(SS-A) antibody positive lupus patients with Sjögren's syndrome (SS/LE) appear to have a more guarded prognosis. Our studies indicate these SS/LE patients have an increased frequency of pulmonary, neurological, and renal disease compared to SCLE patients.
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Provost et al. (1997) studied this question. Anti-Ro(SS-A) antibody positive lupus patients with Sjögren's syndrome have a worse prognosis and higher frequency of pulmonary, neurological, and renal disease compared to SCLE patients.
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