inteoduction Studies concerning the influence of steroid hormones upon connective tissue have, for the most part, been restricted to pelvic or sex organs (Loeb, Suntzeff and Burns, 1939; Gardner and Pfeiffer, 1943; Hall, 1947; Hall and Newton, 1947; Talmage, 1947; Emery and Lawton, 1947). More recently the influence of steroids, particularly desoxycorticosterone acetate, upon the body as a whole with the production of specific or systemic effects has been stressed by Selye (1943, 1944, 1946; Selye, Sylvester, Hall and Leblond, 1944). We desired to study the effects of different steroid hormones on connective tissue in laboratory animals under controlled conditions. We became interested in one particular phase of this problem, i.e. the response of connective tissue to inflammation under the influence of selected steroid hormones. It was thought that one method would be to observe actively growing granulation tissue in experimental animals.
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Taubenhaus et al. (1949) studied this question.
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