Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster—one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired—provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate.
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Maul et al. (2008) studied this question.
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