On the use of PIPSA to Guide Target‐Selective Drug Design

Predicting proteins. PIPSA (Protein Interaction Property Similarity Analysis) provides a means to detect similarities and differences in the interaction fields of structurally related proteins and can therefore assist in identification of regions of proteins to target for selective ligand design. Herein, this is illustrated by application of PIPSA to dihydrofolate reductase, an important drug target.