Why the study?
Does previous PTCA reduce the progression of obstructive coronary artery disease compared to non-PTCA sites in patients undergoing successful PTCA?
Does previous PTCA reduce the progression of obstructive coronary artery disease compared to non-PTCA sites in patients undergoing successful PTCA?
Long-term angiographic follow-up suggests that coronary lesions previously treated with PTCA show less progression and more regression compared to untreated sites.
Answers are grounded in this paper and cite their sources.
PTCA sites may show less progression in cohorts; leaves open causal effects and need for RCTs before practice change.
Long-term follow-up of coronary artery stenosis was carried out in 81 patients undergoing successful percutaneous transluminal coronary angioplasty (PTCA). Progression of coronary stenosis was observed in 38 patients with 52 sites, and regression was seen in 23 patients with 23 sites during 2 years or more of follow-up. Progressive change occurred in three sites of 97 PTCA lesions and 49 of 1,090 non-PTCA lesions (no significant difference). On the other hand, regressive change was observed in 19 sites of PTCA lesions and four of non-PTCA lesions (p < 0.05). The percentage of narrowing in PTCA lesions was 28.0 +/- 14.4% at 3-6 months after PTCA, and this improved to 22.8 +/- 15.8% at late study angiography. Coronary score changes were -0.16 +/- 0.54 in PTCA lesions, and 0.08 +/- 0.46 in non-PTCA lesions (p < 0.01). We concluded that the progression of obstructive coronary artery disease in sites with previous PTCA is less than in those with non-PTCA.
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Ohtani et al. (1995) studied this question.
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