Why the study?
Does cardiac-specific overexpression of beta1-adrenergic receptors alter calcium handling and cardiac function in mice?
Does cardiac-specific overexpression of beta1-adrenergic receptors alter calcium handling and cardiac function in mice?
Cardiac overexpression of beta1-adrenergic receptors in mice leads to early impairment of calcium handling and decreased junctin expression, preceding progressive cardiac dysfunction and failure.
Suggests beta1 overexpression disrupts calcium handling before failure in mice; leaves open human relevance.
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Engelhardt et al. (2001) studied this question.
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