Why the study?
Does intracoronary ultrasound reveal atherosclerotic plaques in the infarct-related vessels of women with myocardial infarction and angiographically normal or non-significantly stenosed vessels compared to noninfarcted control vessels?
Does intracoronary ultrasound reveal atherosclerotic plaques in the infarct-related vessels of women with myocardial infarction and angiographically normal or non-significantly stenosed vessels compared to noninfarcted control vessels?
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Intracoronary ultrasound reveals that atherosclerosis is present in the infarct-related arteries of women with MINOCA, suggesting it may be the main etiologic factor despite the absence of angiographically significant stenosis.
METHODS: Morphologic characteristics of coronary arteries in eight women with myocardial infarction and angiographically normal or not significantly stenosed vessels were investigated with intracoronary ultrasound. The infarct-related vessel was assessed by three-dimensional volumetric analysis and compared with a control vessel from a noninfarcted area. RESULTS: Atherosclerosis was found in all infarct-related arteries. The plaques were predominantly soft, eccentric, poorly calcified, and with little lipid pools or none at all. Although the average area and thickness of plaques and cross-sectional narrowing of the infarct-related arteries were greater than those of control arteries, there were no pathognomonic characteristics of plaques in the infarct-related vessels. CONCLUSION: The possibility that atherosclerosis is the main etiologic factor for myocardial infarction can not be excluded even for women without an angiographically obvious coronary stenosis in the infarct-related vessels.
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Al-Khalili et al. (2000) studied this question.
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