An enantioselective total synthesis of AI-77-B ( 1 ), a gastroprotective substance isolated from a culture broth of Bacillus pumilus AI-77, was performed in high overall yield. In this synthesis, the dihydroisocoumarin part 14 and the dihydroxyamino acid part 20 were both assembled from d -ribose as the common chiral source. For the construction of 14 a bromobenzofuran derivative was used as a novel salicylic acid synthon. Finally, DEPC-mediated condensation of 14 and 20 yielded AI-77-B ( 1 ).
No takes yet. Share an insight, caveat, or question.
Kotsuki et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: