Synthesis and Bioactivity of Sol–Gel Derived Porous, Bioactive Glass Microspheres Using Chitosan as Novel Biomolecular Template

This article reports a novel, simple route for synthesis of sol–gel derived porous, bioactive glass ( BG ) microspheres using chitosan ( CTS ) as a biomolecular template in the acid‐catalyzed sol–gel process. The use of CTS , which is a natural biocompatible polymer with a unique molecular structure, allowed the synthesis of BG microparticles with a spherical shape, 5–10 μm in size. Furthermore, pores with a size of 5–40 nm were created entirely throughout BG microspheres, which were formed by removing the network of CTS present initially in the CTS‐BG composite microparticles via heat‐treatment at 600°C for 2 h. These porous BG microspheres induced the vigorous precipitation of apatite crystals on their surface when immersed in simulated body fluid for 24 h, thus suggesting their excellent bioactivity .