Bionanoprobes with high dispersion stability in water, excellent photostability, and biocompatibility were prepared by encapsulating [Eu(tta)3dpbt] (tta=thenoyltrifluoroacetonato, dpbt=2-(N,N-diethylanilin-4-yl)-4,6-bis-(3,5-dimethylpyrazol-1-yl)-1,3,5-triazine) in water-dispersible poly(methyl methacrylate-co-methacrylic acid) nanospheres and modifying the nanosphere surfaces with a monoclonal antibody (see scheme). The bionanoprobes exhibited excellent performance in the target-specific imaging of live cancer cells.
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Shao et al. (2010) studied this question.
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