Key result
Testicular maturation shifts HMG-CoA reductase mRNA expression from a 4.8-kb form to shorter specific transcripts.
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The developmental expression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the rate-limiting reaction of mevalonate formation, was investigated in rat testes. Adult testes were found to contain three distinct forms of HMG-CoA reductase mRNA of 4.8, 4.2, and 4.0 kilobases (kb) in length. In testes from 26-day-old rats the 4.8-kb species was the major form present. By 40 days of age, large increases in the levels of the testes-specific 4.2- and 4.0-kb forms occurred, with a small decrease in the amount of the 4.8-kb form. The level of the 4.8-kb form appeared to be associated with the level of testicular HMG-CoA reductase activity.
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Ness et al. (1992) studied Developmental expression of HMG-CoA reductase mRNA in rat testes. Developmental age was evaluated on Levels of HMG-CoA reductase mRNA forms. Testes from 26-day-old rats primarily express a 4.8-kb HMG-CoA reductase mRNA, whereas large increases in testes-specific 4.2- and 4.0-kb forms occur by 40 days of age.
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