The level and distribution of static crevicular fluid (SCF) antibody was studied in periodontal disease patients. Elevated levels of SCF antibody were demonstrated in approximately 9% of 1292 sites. The elevated responses were shown to be limited to particular bacterial specificities at any one site. Additional comparisons indicated that the frequency of elevated antibody levels in SCF were most closely related with responses to A. actinomycetemcomitans, B. gingivalis , and B. intermedius rather than clinical categorization.
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Ebersole et al. (1985) studied this question.
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