Profound Hypotension with Differential Cooling of the Brain in Dogs

E FFECTIVE hemostas is is usually attained by rout ine and standardized procedures. However , since the operat ive t r ea tmen t of highly vascularized lesions often requires addit ional hemostat ic measures, unique ad junc ts such as controlled hypotension 2,26,3~176 or hypo the rmic techniques 1'9'1~ have been employed. Indeed, hypotens ive agents have also been used in combinat ion with body-surface cooling, 1,12,1~,21,2s,31,32,4~ while the nervous system has been cooled topically, selectively, or indirectly. Moreover , var ious levels of hypothermia (or more precisely, brain temperatures), ranging f rom 35~ to 10~ have been used. In the lower ranges (or profound hypothermia) , extracorporeal circulation has been applied ei ther as a cardiac bypass , 14,1s, 22,29,33,34,38,42,a3.44,46 or for selective cooling, u, 19,20,24,25