Key result
Defective renal dopamine mobilization is linked to salt-sensitive essential hypertension, particularly in Black patients.
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The formation and action of intrarenal dopamine is reviewed, as also is the evidence for the use of gamma-L-glutamyl-L-dopa as a relatively renally specific dopaminergic pro-drug. 'Salt sensitive' patients with essential hypertension may have a fault in the renal mobilisation of dopamine by sodium chloride. This failure of sodium to dopamine coupling may be particularly prevalent in the Negro race.
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M. R. Lee (1987) conducted a review in Essential hypertension. gamma-L-glutamyl-L-dopa (Gludopa) was evaluated. A review on intrarenal dopamine highlights that salt-sensitive patients with essential hypertension may have a fault in renal dopamine mobilization, potentially prevalent in the Negro race.
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