Why the study?
Does deep grey matter black T2 measured on 3 T MRI correlate with disability in patients with multiple sclerosis?
Does deep grey matter black T2 measured on 3 T MRI correlate with disability in patients with multiple sclerosis?
Deep grey matter T2 hypointensity measured at 3 T MRI correlates with disability in multiple sclerosis patients, suggesting its potential utility as an imaging biomarker.
Deep grey matter T2 hypointensity was associated with disability in MS; hypothesis-generating for biomarker utility, validation studies needed.
T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5 T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3 T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.
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Zhang et al. (2007) studied this question.
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