The presented work introduces a new model of folding kinetics of random heteropolymers, which is based on the free volume concept. This model reproduces the well-known saddlelike temperature dependence of folding time. The presented model is discussed in comparison to the random energy model which is widely employed for describing kinetics of this type and in relation to Levinthal's paradox.
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Yaroslav Ryabov (2003) studied this question.
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