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Renin inhibits compensatory renal hypertrophy and is more active intraperitoneally than subcutaneously. This inhibition, which is caused by renin as such, is not related to the catabolic effect of renin; it is abolished by hypophysectomy. Our experiments suggest that renin, like other hormonal secretions, can act in a self-regulating mechanism in the control of organ growth.
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SCHAFFENBURG et al. (1954) studied this question.
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