October 1, 1984Biochemical JournalOpen Access

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate

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Population

Saponin-treated guinea pig peritoneal macrophages, cardiac sarcoplasmic reticulum, and erythrocyte…

Design

Preclinical

Authors

MHMasato HirataKanazawa University ESEiichi SuematsuOno Clinic THT. HashimotoMusashino Art University

Discussion

Member takes

Implication

Hypothesis-generating for IP3 in cardiac Ca2+ stores; human studies needed before any clinical consideration.

Structured PICO

Population

Saponin-treated guinea pig peritoneal macrophages, cardiac sarcoplasmic reticulum, and erythrocyte inside-out vesicles

Intervention

Inositol 1,4,5-trisphosphate (micromolar concentrations)

Outcome

Ca2+ release from intracellular store sitessurrogate

Inositol 1,4,5-trisphosphate induces rapid calcium release from non-mitochondrial intracellular stores in macrophages and cardiac sarcoplasmic reticulum.

Cite This Study

Hirata et al. (1984) studied this question.

synapsesocial.com/papers/6a6fdd6375498292b7093ddd https://doi.org/10.1042/bj2230229

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Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider