Why the study?
Vitamin K deficiency bleeding causing massive bleeding beyond 3 months of age in an otherwise healthy child is extremely rare.
Answers are grounded in this paper and cite their sources.
Vitamin K deficiency bleeding should be considered in infants beyond the typical age group if they have delayed introduction of complementary feeds.
Vitamin K deficiency bleeding (VKDB) is a well-known entity in the newborn period, classically presenting during the first week of life. VKDB causing massive bleeding beyond 3 months of age, in an otherwise healthy child, is extremely rare. We present a rare case of massive intracranial bleed in an infant who had received routine vitamin K prophylaxis at birth. His blood investigations revealed severe anemia with a grossly deranged coagulation profile and high proteins induced by vitamin K absence (PIVKAII). His coagulation parameters normalised within 12 hours of Vitamin K and a single dose of FFP. He was a well-nourished child with no evidence of malabsorption. He had no risk factors for VKDB except for extended exclusive breastfeeding. His coagulation profile remained normal at the 6-month review, also. VKDB should be considered outside the typical age group in a child with delayed introduction of complementary feeds.
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Jayan et al. (2025) studied this question.
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