Cyclic Acute Agranulocytosis: Report of a Case, With Improvement After Splenectomy

Case Reports1 December 1951CYCLIC ACUTE AGRANULOCYTOSIS: REPORT OF A CASE, WITH IMPROVEMENT AFTER SPLENECTOMYJOSEPH F. SANDELLA, M.D.JOSEPH F. SANDELLA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-6-1365 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSingle episodes of acute agranulocytosis caused by drugs, poisons, roentgen-ray or ionizing radiation are common, and their pathology and clinical course are well known. Transient neutropenia occurs following many infectious diseases, and chronic neutropenia is present in cases of bone marrow hypoplasia as well as in conditions associated with infiltration of the bone marrow.Since the concept of hypersplenism was first advanced by Wiseman and Doan,1a variety of clinical syndromes has been described in which either acute or chronic neutropenia or a combination of both phases occurs as a selective entity or as part of a pancytopenia affecting all...Bibliography1. WisemanDoan BKCA: Primary splenic neutropenia, Ann. Int. Med. 16: 1097, 1942. LinkGoogle Scholar2. Reimann HA: Periodic disease, J. A. M. A. 136: 239, 1948. CrossrefMedlineGoogle Scholar3. Reimann HA: Periodic disease, J. A. M. A. 141: 175, 1949. CrossrefMedlineGoogle Scholar4. Reimannde Berardinis HACT: Periodic (cyclic) neutropenia, an entity, collection of sixteen cases, Blood 4: 1109, 1949. CrossrefMedlineGoogle Scholar5. Owren PA: Cyclic agranulocytosis, Acta med. Scandinav. 134: 87, 1949. CrossrefMedlineGoogle Scholar6. FullertonDuguid HWHL: A case of cyclic agranulocytosis with marked improvement following splenectomy, Blood 4: 269, 1949. CrossrefMedlineGoogle Scholar7. HeinleHolden RWWD: Primary splenic panhematopenia, Surg., Gynec. and Obst. 89: 79, 1949. MedlineGoogle Scholar8. StephensLawrence DJJS: Cyclic agranulocytic angina, Ann. Int. Med. 9: 31, 1935. LinkGoogle Scholar9. SingerMillerDameshek KEBW: Hematological changes following splenectomy in man, Am. J. M. Sc. 202: 171, 1941. CrossrefGoogle Scholar10. Jackson H: Agranulocytosis, Ann. Int. Med. 9: 26, 1935. LinkGoogle Scholar11. Leitner SJ: Bone marrow biopsy, 1949, Grune and Stratton, New York. Google Scholar12. PineyPaterson AJS: Sternal puncture, 1946, Grune and Stratton, New York. Google Scholar13. DoanWright CACS: Primary congenital and secondary acquired splenic panhematopenia, Blood 1: 10, 1946. CrossrefMedlineGoogle Scholar14. Doan CA: Primary splenic panhematopenia, J. Lab. and Clin. Med. 30: 385, 1945. Google Scholar15. Doan CA: Hypersplenism, Bull. New York Acad. Med. 25: 625, 1949. MedlineGoogle Scholar16. DameshekEstren WS: The spleen and hypersplenism, 1947, Grune and Stratton, New York. Google Scholar17. DameshekMiller WEB: Megakaryocytes in idiopathic thrombocytopenic purpura, Blood 1: 27, 1946. CrossrefMedlineGoogle Scholar18. Hirschboeck JS: Hematological effects of splenectomy in Still-Chauffard-Felty syndrome, Blood 1: 247, 1946. CrossrefMedlineGoogle Scholar19. MuetherMooreStewartBrown ROLTJWGO: Chronic granulocytopenia caused by excessive splenic lysis of granulocytes, J. A. M. A. 116: 2255, 1941. CrossrefGoogle Scholar20. WeissCollins HAWT: Chronic neutropenia: favorable response following splenectomy, Blood 4: 278, 1949. CrossrefMedlineGoogle Scholar21. KrackeRiser RRWH: Hypersplenism, J. A. M. A. 141: 1132, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Brunswick, New Jersey*Received for publication March 3, 1950. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySolid Variant of Aneurysmal Bone Cyst in a Patient with Cyclic NeutropeniaAdult-onset cyclic bicytopenia: A case report and review of treatment of cyclic hematopoiesisCyclic neutropenia as a premalignant manifestation of acute lymphoblastic leukemiaHematologic Aspects of Malignant Lymphoproliferative DiseasePeriodic neutropenia and monocytopeniaCyclic neutropenia and T lymphocyte suppression of granulopoiesis: Abrogation of the neutropenic cycles by lithium carbonateZellkinetische Untersuchungen zur Klärung der Ursache periodischer Schwankungen des Neutrophilenspiegels im Blut bei einem Fall von zyklischer NeutropenieAtaxia telangiectasia with granulocytopeniaFamilial Cyclical Neutropenia�ber die famili�re NeutropenieCyclic neutropeniaCyclical neutropeniaIndikationen zur Splenektomie bei BlutkrankheitenCyclic Neutropenia Report on Three CasesPeriodontal Manifestations of Cyclic NeutropeniaLymphosarkom-Leuk�mie, cyclische Agranulocytose und latente Neutropenie in einer Familie 1 December 1951Volume 35, Issue 6Page: 1365-1371KeywordsBone marrowClinical pathologyHemorrhageInfectious diseasesIonizing radiationLiverLymph nodesNeutropeniaSpleenSplenectomy ePublished: 1 December 2008 Issue Published: 1 December 1951 PDF downloadLoading ...