Primary Splenic Hodgkin's Disease Without Lymph Node Involvement

Case Reports1 August 1947PRIMARY SPLENIC HODGKIN'S DISEASE WITHOUT LYMPH NODE INVOLVEMENTNORMAN H. ISAACSON, M.D., SAMUEL D. SPATT, M.D., DAVID M. GRAYZEL, M.D., Ph.D.NORMAN H. ISAACSON, M.D.Search for more papers by this author, SAMUEL D. SPATT, M.D.Search for more papers by this author, DAVID M. GRAYZEL, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-2-294 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1832 Hodgkin1 called attention to the existence of a disease characterized by progressive enlargement of the lymph nodes and associated in many instances with enlargement of the spleen. Seventy-five years later Reed2 stated "we know of no case where the pathological anatomy was described in sufficient detail to permit of a positive diagnosis in which the disease commenced elsewhere than in the lymph nodes." Even today most medical authors deny the existence of a primary splenic form of the disease.Symmers,3however, in 1909 described a case of an 18 year old girl with recurrent chills and fever and...Bibliography1. HODGKIN T: Trans. Med. Chir. Soc., London, 1832, xvii, 68. CrossrefGoogle Scholar2. REED DM: Pathological changes in Hodgkin's disease with especial reference to tuberculosis, Johns Hopkins Hosp. Rep., 1902, x, 133. Google Scholar3. SYMMERS D: Certain unusual lesions of the lymphatic apparatus, Arch. Int. Med., 1909, iv, 218. CrossrefGoogle Scholar4. WADE AW: Primary Hodgkin's disease of spleen, Jr. Med. Res., 1913, xxix, 209. Google Scholar5. DOWD CN: Splenectomy for the splenic form of Hodgkin's disease, Ann. Surg., 1917, lxv, 785. Google Scholar6. KRUMBHAAR EB: Hodgkin's disease of bone marrow and spleen without apparent involvement of lymph nodes, Am. Jr. Med. Sci., 1931, clxxxii, 764. Google Scholar7. SEARSBLACK : Hodgkin's disease without lymphadenopathy, Colorado Med., 1932, xxix, 208. Google Scholar8. BORDONI-POSSIARDAO RPH: Malignant lymphogranuloma of the spleen, Arch. urug. de med., cir. y especialid., 1935, vii, 33. Google Scholar9. GEBAUER : Acute isolated lymphogranulomatosis of spleen, Deutsch. Arch. f. klin. Med., 1939, clxxxv, 338. Google Scholar10. VELASCO MONTES F: Puncture of spleen as diagnostic method in aleukemic lymphadenosis and in differential diagnosis of various splenomegalies, especially of pure lymphogranulomatosis, Med. Klin., 1939, xxxv, 249. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication February 5, 1946.From the Department of Laboratories, Jewish Hospital of Brooklyn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase 8-1970 1 August 1947Volume 27, Issue 2Page: 294-301KeywordsFeversHodgkin lymphomaLymph nodesProgressive diseasesSpleen ePublished: 1 December 2008 Issue Published: 1 August 1947 PDF downloadLoading ...