Lipid Biosynthesis in Anoxic‐ischaemic Rat Brain*

The uptake of [U‐ 14 C]glucose and [2‐ 14 C]acetate into lipids was measured in brain slices from anoxic, unilaterally ischaemic, unilaterally anoxic‐ischaemic, and control rats. The rate of incorporation was significantly decreased in the brain slices from the treated animals except for the contralateral hemisphere of the unilaterally ischaemic animals. Also, there was no significant difference between the anoxic and the anoxic‐ischaemic cerebral hemispheres of the anoxic‐ischaemic animals. Fractionation of the total lipid extract demonstrated that the decrease in incorporation was general and not due to any particular class of lipid.