SummaryThe data provide another example of the control of the genetic constitution of microorganisms by specifically oriented desoxyribonucleic acids. An R strain, Rbl, derived from type b H. influenzae was endowed with properties of type b under the influence of a desoxyribonucleic acid isolated from type b H. influenzae. This same R strain, Rbl, was transformed to type c H. influenzae when grown in an appropriate environment in the presence of an unpurified transforming principle isolated from type c H. influenzae.Rbl has also been transformed to Sa and Sd. The transforming activity of desoxyribonucleic acid has been shown to be destroyed by a crystalline desoxyribonuclease supplied by Dr. Maclyn McCarty.
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Alexander et al. (1950) studied this question.