There is a critical need for consensus on standardized animal models in peritoneal dialysis research to improve comparability and interpretation of studies.
Animal model variability in peritoneal dialysis research warrants cautious interpretation before clinical translation; leaves open consensus on an optimal standardized model.
The development of an adequate animal model for peritoneal research remains an object of concern. In vivo peritoneal dialysis (PD) research is hampered by the large variety of available models that make interpretation of results and comparison of studies very difficult. Species and strain of experimental animals, method of peritoneal access, study duration, measures of solute transport and ultrafiltration, and sampling for histology differ substantially among the various research groups. A collective effort to discuss the shortcomings and merits of the different experimental models may lead to a consensus on a standardized animal model of PD.
No takes yet. Share an insight, caveat, or question.
Mortier et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: