The MHC class I H chain and the L chain that assembles with it, β2-microglobulin (β2m),[3][1] are cotranslationally inserted into the lumen of the endoplasmic reticulum (ER) ([1][2]). In the ER, the MHC/β2m heterodimer binds peptide that is generated by proteasomal protein degradation in the
No takes yet. Share an insight, caveat, or question.
Petersen et al. (2003) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: