A straightforward approach: An unprecedented zirconocene-catalyzed isomerization–magnesation reaction of readily available alkene-substituted enol ethers allows the direct synthesis of functionalized Grignard reagents. Cp=cyclopentadienyl.
No takes yet. Share an insight, caveat, or question.
Barluenga et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: