Gold nanoparticle labels enable the position of receptors (concanavalin A) bound to multivalent ligands (see picture; top: straptavidin-conjugated gold particles, middle: receptors, bottom: ligand) assembled using the ring-opening metathesis polymerization to be determined by transmission electron microscopy. The number of concanavalin A tetramers incorporated into the receptor–ligand complexes depends on the ligand valency. The results illustrate a general approach for the elucidation of the stoichiometry of individual multivalent ligand–receptor complexes, which is critical for understanding the mechanism of multivalent binding events.
No takes yet. Share an insight, caveat, or question.
Gestwicki et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: