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September 1, 1972Journal of Medicinal Chemistry

Synthesis and antiprotozoal activity of methylnitro derivatives of 2,2'-biimidazole

Piero Melloni E. Dradi Willy Logemann Ivo de Carneri Franca Trane

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Abstract

We synthesized a series of 2,2'-biimidazoles with different substituents and screened them against Entamoeba histolytica, Trichomonas vaginalis and Giardia muris. A 5-nitro group is necessary for the inclusion of activity and an amino group exercises favourable effect on in vivi activity.

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Melloni et al. (1972) studied this question.

synapsesocial.com/papers/6a6ff0e526770c2b8de03e44 https://doi.org/10.1021/jm00279a012

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