August 4, 2009CirculationOpen Access

Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3 , as Regulators of Myocardial Repolarization

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Population

Zebrafish model of cardiac repolarization using fluorescent reporters of transmembrane potential

Design

Preclinical

Authors

DMDavid J. MilanElectrophysiology AKAlbert M. KimInternational Neuromodulation Society JWJeffrey R. WinterfieldBrigham and Women's Hospital

Discussion

Member takes

Implication

Zebrafish screen nominates GINS3 and 14 other genes for QT regulation; leaves open mammalian validation and clinical translation.

Structured PICO

Population

Zebrafish model of cardiac repolarization using fluorescent reporters of transmembrane potential

Intervention

Drug-sensitized genetic screen

Outcome

Identification of genes affecting cardiac repolarizationsurrogate

A drug-sensitized zebrafish screen identified 15 novel genes, including GINS3, that regulate cardiac repolarization and are associated with QT interval in humans.

Cite This Study

Milan et al. (2009) studied this question.

synapsesocial.com/papers/6a6ff13331a3df8243283c36 https://doi.org/10.1161/circulationaha.108.821082

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Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3 , as Regulators of Myocardial Repolarization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3 , as Regulators of Myocardial Repolarization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider