In 25 patients with decompensated (n = 16) and compensated (n = 9) autonomous adenoma, the thyroid hormones in serum and the TSH response before operation was compared with intrathyroidal total iodine (TI), PBI, T4 -RIA, T3-RIA and T4/T3 ratio. Autonomous nodular tissue (ANT) and paranodular tissue (PNT) of the operated thyroid gland were hydrolyzed with Pronase under anaerobic conditions. TI, PBI, T4 and T3 were measured in the hydrolysates.
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Reinwein et al. (1977) studied this question.