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March 15, 1995Genes & DevelopmentOpen Access

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

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Authors

SMSatomi MatsuokaMEMichael C. EdwardsCBChang-Ming Bai

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Overview

Molecular analysis demonstrates p57KIP2 induces cell cycle arrest and developmental regulation, indicating its function as a potential tumor suppressor.

Key Points

  • To identify and characterize p57KIP2, a novel member of the p21CIP1 cyclin-dependent kinase inhibitor family, and investigate its role in cell cycle control and development.
  • Assayed p57KIP2 biochemical binding affinities with G1 cyclin/Cdk complexes and evaluated cell cycle arrest upon overexpression.
  • Tracked spatial and temporal mRNA expression patterns during mouse embryogenesis using in situ hybridization.
  • Mapped the chromosomal location of human p57KIP2 relative to known cancer-associated loci.
  • p57KIP2 bound tightly to G1 cyclin/Cdk complexes in a cyclin-dependent, p53-independent manner and arrested cells in the G1 phase.
  • In situ hybridization revealed marked p57KIP2 expression in terminally differentiated embryonic tissues, including skeletal muscle, heart, brain, lungs, and eye.
  • Human p57KIP2 was mapped to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and sporadic cancers.

Cite This Study

Matsuoka et al. (1995) studied this question.

synapsesocial.com/papers/6a6ff370e5469ee92be0befehttps://doi.org/10.1101/gad.9.6.650
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