March 14, 2009AJP Heart and Circulatory Physiology

Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat

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Population

Later-stage (32-38 wk old) type 2 diabetic Goto-Kakizaki (GK) rats and control Wistar rats

Comparison

Endothelin-1 and various pharmacological agents vs Control Wistar rats

Design

Preclinical

Authors

TMTakayuki MatsumotoUniversity of Miyazaki KIKeiko IshidaKao Corporation (Japan)NNNaoaki NakayamaHoshi University

Discussion

Member takes

Implication

ET(A) targeting may merit exploration in diabetic vasculopathy; leaves open translation from this rat model to human disease.

Structured PICO

Population

Later-stage (32-38 wk old) type 2 diabetic Goto-Kakizaki (GK) rats and control Wistar rats

Intervention

Endothelin-1 (ET-1) and various pharmacological agents (IRL1620, BQ-123, BQ-788, l-NNA, sodium nitroprusside, PD-98059, U0126)

Comparator

Control Wistar rats

Outcome

ET-1-induced contraction and relaxation induced by IRL1620 in mesenteric arteriessurrogate

In later-stage type 2 diabetic rats, hyperreactivity to endothelin-1 in mesenteric arteries is mediated by ET(A) upregulation, defective ET(B)-mediated NO signaling, and MEK/ERK pathway activation.

Cite This Study

Matsumoto et al. (2009) studied this question.

synapsesocial.com/papers/6a6ff3ac31a3df8243283e89 https://doi.org/10.1152/ajpheart.00043.2009

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Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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