An added dimension: Amphiphiles with two-dimensional hydrophobic and hydrophilic faces represent a departure from traditional one-dimensional polar-head/nonpolar-tail molecules for the stabilization of integral membrane proteins. A prototypical example of this design has been synthesized from cholic acid (see picture), and was successfully used in the stabilization of two integral membrane proteins (represented by the blue/green cylinder).
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Zhang et al. (2007) studied this question.
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