A comparative study between intralesional 5-fluorouracil combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of keloids

Background: Many modalities of keloid treatment have been advocated which have a variable and transient success. There is no universally accepted treatment resulting in permanent cure. Hence there is need for evaluation of better modalities to achieve good cosmetic acceptability. Current study compares the efficacy and safety of intralesional 5-fluorouracil combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of keloids.Methods: Cases of clinically diagnosed keloids from South Central Railway Hospital were included in the study. These patients were randomly allocated alternately between group 1 and 2. An interventional and comparative study, comparing the percentage reduction in volume of keloid between both groups after treatment was done. For group 1 intralesional injection 5-fluorouracil 0.9 ml (50 mg/ml) combined with 0.1 ml of triamcinolone acetonide (40 mg/ml) i.e., 45 mg of 5 Fluorouracil was combined with 4 mg of triamcinolone, weekly once for 8 weeks. For group 2 intralesional triamcinolone acetonide 10 mg/ml alone weekly for 8 weeks. Volume of keloid (i.e., (length x breadth x height measured by vernier calipers) before starting treatment and one week after the last injection was compared. percentage reduction in the volume was calculated.Results: The overall therapeutic response in volume reduction in group 1 was found to be better and statistically significant (p value<0.01) compared to group 2.Conclusions: The present study has shown that intralesional 5-FU+TAC is more effective compared to TAC intralesional injection alone.