Why the study?
Does knocking out the isk gene affect the QT interval adaptation to heart rate variations in a murine model of Jervell and Lange-Nielsen syndrome?
Does knocking out the isk gene affect the QT interval adaptation to heart rate variations in a murine model of Jervell and Lange-Nielsen syndrome?
The isk gene product blunts QT adaptation to heart rate variations, suggesting that steeper QT-RR relationships reflect greater arrhythmia susceptibility in patients lacking IKs.
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Isk knockout exaggerates QT adaptation to cycle length in mice; leaves open whether steeper QT-RR slopes mark arrhythmia risk in JLNS.
Drici et al. (1998) studied this question.
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