Population
Sarcoplasmic reticulum Ca2+-ATPase (purified vesicles and solubilized with C12E8)
Comparison
Solubilization with C12E8 in the presence or… vs Purified ATPase vesicles
Design
Preclinical
Authors
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Preserves Ca2+ cooperativity only with millimolar calcium during solubilization; leaves open relevance to native SR ATPase function in cardiomyocytes.
The study demonstrates that the cooperative binding of Ca2+ to sarcoplasmic reticulum ATPase is lost upon solubilization but can be preserved if solubilized in the presence of millimolar calcium, suggesting a model of interacting Ca2+ sites.
Verjovski‐Almeida et al. (1981) studied this question.
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