Intrinsic fluorescence as a probe of structure-function relationships in Ca2+-transport ATPases

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Population

Ca(2+)-transport ATPases (sarcoplasmic reticulum and plasma membrane)

Design

Review

Authors

Discussion

Supports spectroscopic probing of Ca2+-ATPase dynamics in research; leaves open clinical translation to cardiac therapies.

Population

Ca(2+)-transport ATPases (sarcoplasmic reticulum and plasma membrane)

Intervention

Intrinsic fluorescence measurements (steady-state and time-resolved fluorescence spectroscopy)

Outcome

Structure-function relationships, ligand-induced conformational changes, and protein interactions

Intrinsic fluorescence is a valuable tool for investigating the structural and functional dynamics of Ca2+-transport ATPases.

Ferreira et al. (1996) studied this question.

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